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Allyl-mercapto-captopril (CPSSA - Captosal) (Yeda)
code: 179
David Mirelman, Biochemistry, Biological Chemistry

Summary

179 - Allyl-mercapto-captopril (CPSSA - Captosal)

Description: Conjugation between allicin (the biologically active molecule in garlic) and captopril, a known antihypertensive drug. Was shown to offer therapeutic benefits for the treatment of the metabolic syndrome, as demonstrated by various animal models. These include improvement of glucose tolerance, preventing weight gain, lowering blood pressure, reducing cardiac hypertrophy and potent antioxidant activities.

Reference: Miron T, Rabinkov A, Peleg E, Rosenthal T, Mirelman D, Wilcheck M. 2004. Allylmercaptocaptopril: a new antihypertensive drug. Am. J. Hypertens. 1:71-73.

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Licensing Officer,
Yeda Research and Development Co. Ltd. - Technology Transfer from the Weizmann Institute. P.O. Box 95, Rehovot,76100, Israel. Tel: +972-8-947-0617 Fax: +972-8-947-0739 SMS: +972-8-936-6874
ITTN - Israel Tech Transfer Organization