Monoclonal antibodies for peptide and steroid hormones
Due to their high specificity and sensitivity these antibodies may be applicable for research, diagnosis and therapeutics. A particular use may be quality control of industrial manufacturing of food products.
§ 127, 274, 141 – Monoclonal antibodies to estradiol Description: Monoclonal antibodies raised against oestradiol-6- carboxymethyl oxime-BSA. Available clones: 2F9 (Rat, IgG2a), 15 (IgG2b), 8D9 (IgG2a).
Estradiol is a sex hormone, which has not only a critical impact on reproductive and sexual functioning, but also affects other organs, including the bones. In the female, estradiol acts as a growth hormone for tissues of the reproductive organs.
References: De Boever J, Kohen F, Usanachitt C, Vandekerckhove D, Leyseele D, Vandewalle L. 1986. Direct chemiluminescence immunoassay for estradiol in serum. Clin Chem. 32(10):1895-900.
S?mjen D1, Amir-Zaltsman Y, Mor G, Gayer B, Lichter S, Nevo N, Kohen F. 1998. A monoclonal antibody to oestradiol potentiates the stimulation of the specific activity of the brain type creatine kinase by oestrogen in vivo and in vitro. J Steroid Biochem Mol Biol. 64(5-6):297-304.