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Background:According to the amyloid hypothesis, accumulation and oligomerization of amyloid β-peptide (Aβ) in the brain because of its inefficient clearance is the primary pathogenic event in Alzheimer’s disease (AD). In healthy brains, soluble Aβ is rapidly cleared via mechanisms that ...
Scientific Contact: Shai Rahimipour
Background:The actin cytoskeleton and its regulatory proteins are significant players in cell movement, tissue invasion and metastasis by cancerous cells. For these to occur, actin polymerization and remodeling is required. The Wiskott-Aldrich syndrome protein (WASp) is an actin nucleation ...
Scientific Contact: Mira Barda-Saad
Background:Many diseases result from mutations on specific genes that cause proteins (often enzymes) with reduced activity to be produced. Reduced activity results from protein misfoldng leading to instability and sometimes to protein aggregation. Pharmacological chaperones are an innovative ...
Scientific Contact: Arie Gruzman
Background:Many diseases result from mutations on specific genes that cause proteins (often enzymes) with reduced activity to be produced. Reduced activity results from protein misfoldng leading to instability and sometimes to protein aggregation. Pharmacological chaperones are an innovative ...
Scientific Contact: Arie Gruzman
Background:Several viruses exploit the highly sulfonated cellular polysaccharide heparan sulfate (HS) as a docking site during infection, relying on polyvalent interactions between viral envelope glycoporteins and cell surface heparan sulfate for attachment and entry. Interfering with heparan ...
Scientific Contact: Aharon Gedanken
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*TTO - Technology Transfer Organization
ITTN - Israel Tech Transfer Organization