Technology Opportunities

THE NEED Currently available treatment options for AD are symptomatic and do not modify the progression of the disease. This disease-modifying technology achieves previously unattainable blockage of cognitive deterioration in AD. The technology reverses the Aβ40/42 decline leading to ...

Our work proposes a specific method to treat epilepsy by reducing activity set-points inhippocampal circuits. In particular, we identified mitochondrial dihydroorotate dehydrogenase (DHODH) enzyme as a central regulator of firing set-points in hippocampal circuits. Inhibition of cerebral DHODH ...