The localization precision which is limited by the square root of N is obtained due to non-coherent addition of the collected photons. An increase in the precision is required as it leads to significant increase in the imaging resolution for the same amount of illumination of alternatively it allows the same resolution as in conventional PALM microscopes but obtained in much shorter image construction/collection time.
Our cutting-edge invention allows increasing the precision to approach the limit of N (instead of square root of N) by proper PSF shaping yielding better localization precision and coherent addition of the photons. The proposed unique architecture includes a light source or illuminating the sample, an objective lens for capturing the light emitted from the illuminated sample and a dispersive optical element through which the signal beam is directed and which converts the signal beam (from spatially incoherent) into a spatially coherent beam.
The Commercial Benefit
The proposed invention significantly enhances the performance of commercial fluorescent PALM microscopes.
The global microscopy market is projected to reach USD 7.39 Billion by 2022 from USD 5.60 Billion in 2017, at a CAGR of 5.7%. The market growth is attributed to the favorable government and corporate funding for R&D in microscopy, technological advancements in microscopes as well as favorable regulatory scenario. Moreover, factors such as growth opportunities in emerging markets, increasing application areas of microscopy, and integration of microscopy with spectroscopy offer cost-effective opportunities for the market players.
• Microscopy market
• Fluorescence microscopy market
Team: Primary Inventor
Prof. Zeev Zalevsky
• Prof. Zeev Zalevsky is head of the Electro-Optics study program at the Faculty of Engineering and director of the Nano PhotonicsCentre at the Institute of Nanotechnology and Advanced Materials (BINA).
• Zalevsky's research focuses on the generation and manipulation of light for use in ultra-small applications for high-speed information processing and biological sensing.
• Prof. Zalevsky has developed next-generation optical fibers for micro-endoscopy and for communication networks.
• Development of super resolved nanoscopy systems being STED like for failure analysis of micro electronic chips.
We are looking for investors that are willing to support the research and commercialize this novel invention.