Monoclonal antibody to Runx-3 Description: Monoclonal antibody to Runx-3 raised against the Runx3 peptide TPSTPSPRGSLSTTSHF. Available clones: 62, H8. Runx-3 (Runt-related transcription factor 3) is a transcription factor, and a master regulator of lineage specific gene expression in several important developmental pathways. It binds to the core DNA sequence 5'-YGYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It functions as a tumor suppressor, and is frequently deleted or transcriptionally silenced in cancer.
Reference: Levanon D1, Bernstein Y, Negreanu V, Bone KR, Pozner A, Eilam R, Lotem J, Brenner O, Groner Y. 2011. Absence of Runx3 expression in normal gastrointestinal epithelium calls into question its tumour suppressor function. EMBO Mol Med. 3(10):593-604.