Novel heterocyclicals inhibit quorum sensing
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Categories |
Formulation, Dental Care, Biofilms |
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Development Stage |
Various field trials in process |
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Patent Status |
Patent pending; additional patent to be filed shortly |
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Market |
Biofilms cost millions of dollars each year in medical and nosocomial infections, product contamination, equipment damage, energy losses |
Highlights
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Quorum sensing takes place in biofilms where microbes such as bacteria and fungi are at close proximity to one another
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Inter species quorum sensing may affect microbes’ physiology and virulence properties, resulting in the enhanced virulent properties of biofilms
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Prevents formation of biofilms as well as disruption of existing biofilms
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Many applications in health, water systems, for sterilization of large surfaces, such as walls and floors, in prevention of biofouling and bioerosion
Our Innovation
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Synthesis of novel thiazolidinediones that present a new anti-microbial approach by interfering with the quorum sensing of bacteria and fungi in biofilms
Key Features
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Compounds used are not lethal to bacteria – they are used at concentrations lower than the MIC (minimal inhibitory concentration) - greatly reduces the development of resistance
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Can be used together with known antibiotics and biocides at much lower concentrations
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May be used to prevent formation of biofilms as well as disruption of existing biofilms
Development Milestones
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Seeking investment and industrial cooperation for commercialization
The Opportunity
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Development for use as a non-antibiotic approach to infection therapy
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Medical applications to prevent biofilms in catheters and tubing; large surface sterilization
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Useful in any water system to counteract biofouling – filtration membranes, air conditioning, desalination and more
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Prevention of biofouling of irrigation systems using recycled water
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