Technology Opportunities

Objective/function

• The Antioxidants, Reactive Oxygen Species and Oxidative Stress Laboratory is active in the field of antioxidant-related research: their mechanism, natural compounds, and designing new antioxidants; hypothesis formulation on in vivo antioxidant action; network regulation; delivery enhancement; oxidative stress in the aging process; biological oxidation-reduction (redox) potential; new approaches for evaluating biological redox state; ROS-related diseases; polyphenols and their activity in vitro and in vivo, development of new methodologies, biosensors

Research provided

The laboratory is currently engaged in research in:

• Modulation of the total antioxidant capacity of the organism by exogenous antioxidants
• Oxidation in the gastrointestinal tract and its relevance to various diseases
• The existence of a common mechanism for different types of stress
• How antioxidants work in vivo
• New approaches for quantification of the biological redox state
• Oxidation processes in the brain and its relevance to brain pathologies
• The mechanism of activity of polyphenols

Advantages

• The laboratory is staffed by highly skilled, experience researchers utilizing state-of-the-art equipment and technologies

Available equipment

• The Antioxidants, Reactive Oxygen Species and Oxidative Stress Laboratory can perform
• Tissue cultures
• Spectroscopy methods (E.g. Electron spin resonance, UV, Fluorescence, chemiluminescence)
• Separation techniques
• Cell biology techniques
• Animal models of disease states associated with oxidation
• In vitro simulation of biological oxidation process
• Electrochemical techniques (E.g. voltammetric measurements)

Staff

• Ron Kohen, PhD
• Ran Numa (PhD candidate)
• Meital Portugal (PhD candidate)
• Erez Koren (PhD candidate)
• Shlomit Gurelik (PhD candidate)
• Esther Kanyvski (PhD candidate)

Contact

• Ron Kohen, PhD ronk@ekmd.huji.ac.il