Technology Opportunities

BGN (42)
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Technion (25)
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Yeda (41)
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CD84 - a Novel Regulator of B-CLL Survival (Yeda)
Summary Chronic lymphocytic leukemia (CLL), a malignant disease characterized by the accumulation of B lymphocytes in the blood, lymphoid organs, and bone marrow, is the second most common type of leukemia in adults, accounting for about 7,000 new cases of leukemia each year. Presently, there is no ...
Scientific Contact: Idit Shachar
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Cell manipulation using nanoparticles and short laser pulses (Technion)
The present technology involves the use of nanoparticles and laser light to manipulate selected cells for cancer therapy, tissue regeneration and drug ...
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Cell Therapy to Neurodegenerative Diseases (BGN)
Scientific Contact: Alon Monsonego
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Cells containing a nanopatch sensor in their membrane (BGN)
Scientific Contact: Jelinek Raz
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Ceramide-based Liposomal Drug for the Treatment of Multi-Drug Resistant Cancer (Yissum)
Category Life Sciences and Bio Technology Keywords Chemotherapy, Drug resistance * The project is conducted in collaboration with Memorial Sloan-Kettering Cancer Center. Application Cells with multidrug resistance (MDR) due to aberrant expression of the lipid transporter ...
Scientific Contact: Yechezkel Barenholz
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Chemical Preparation of Polyubiquitin Chains (BGN)
Scientific Contact: Ashraf Brik
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Chemical Preparation of Ubiqitin Thioesters and Modifications Thereof (BGN)
Scientific Contact: Ashraf Brik
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Cholesterol Antibodies (Yeda)
Summary Description: Monoclonal antibodies specific for cholesterol/ceramide-rich domains (clones 405F, 14F, 499F) and cholesterol micro-domains (clones 36A1, 5881) in cell membranes.Originally raised against an artificial monolayer of lipid mixtures in, and were shown to specifically label the ...
Scientific Contact: Lia Addadi
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Combinations of corroles and statins (Technion)
High blood cholesterol level is a main and well established risk factor for the development of cardiovascular disease. Statins, inhibitors of cholesterol biosynthesis, are the leading drugs for reducing cholesterol levels and the most prescribed pharmaceuticals worldwide. We have created ...
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Composition Comprising Red Microalgae Polysaccharides and Metals (BGN)
Scientific Contact: Shoshana Arad (Malis)
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Compositions and Methods for Diagnosing and Treating an Inflammation (Technion)
A method of treating multiple sclerosis (MS) in a subject in need thereof, the method comprising administering to said subject a therapeutically effective amount of an isolated polypeptide comprising an antigen recognition ...
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Conjugates of a Phospholipid and a Drug for the Treatment of Inflammatory Bowel Disease (BGN)
Scientific Contact: Arik Dahan
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Corroles for treatment of diseases (Technion)
Corroles are synthetic, porphyrin molecules that can act as catalytic antioxidants. Corrole derivatives can be used for lowering the probability of developing chronic kidney disease, especially diabetic nephropathy, for which there are currently no approved therapeutic drugs. Additionally, they ...
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Deep nanopatterning focused ion beam technology (Technion)
Focused ion beam (FIB) technology is widely used in the semiconductor industry. FIB etching is used to develop and modify optoelectronic and microelectronic devices. However, FIB technology is limited to large scale devices and is incompatible with the industry trend to reduce device dimensions. ...
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Desaturase Defective Mutant Gene Use Thereof (BGN)
Scientific Contact: Sammy Boussiba
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Development of Anti Necrotic Drugs for Prevention (BGN)
Cell death can occur through two main mechanisms, apoptosis or necrosis. Apoptosis is a tightly regulated physiological process and many of the biochemical pathways involved are well characterized. Necrosis, the outcome of severe and acute injury, has been until lately generally viewed as an ...
Scientific Contact: Eli Lewis
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Disrupting or Preventing Formation of Biofilm by Enzyme Inhibitors (Yeda)
Summary Biofilm is a complex colony of bacteria, which are attached together by extracellular polymeric substance. This setting provides the bacteria protection against environmental factors, improves their surface attachment, and plays a major role in resistance to treatment. Therefore, biofilms ...
Scientific Contact: Ilana Kolodkin-Gal
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Effective Nanoscale Delivery System as an anti-Leishmania drug/ technological platform for drug delivery (BIRAD)
BACKGROUNDLeishmania parasites cycle between two hosts, insect host and mammalian macrophages. Infection in the mammalian host is caused by proliferation within macrophages, especially present in liver and spleen (visceral) or within macrophages in the skin (cutaneous Leishmaniasis). Leishmania ...
Scientific Contact: Shulamit Michaeli
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Enhanced Secretion of Proteins by Tag-Cleaving Cellular System (Yissum)
Protein Secretion is a fundamental aspect in production of therapeutic proteins in eukaryotic cells. Most therapeutic proteins are produced as secreted proteins in mammalian cells such as CHO and HEK293. An essential milestone in the production scheme is the amount of produced protein, since ...
Scientific Contact: Tsafi Danieli
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ERBB2 as a Novel Target to Treat Heart Failure by Inducing Cardiomyocyte Proliferation (Yeda)
Summary Existing treatments fail to compensate the irreversible loss of functional cardiomyocytes (CM), thus presenting a major medical unmet need. Inducing native CM replacement is one approach being tested as regenerative treatment, with the advantage of a more straightforward methodology over ...
Scientific Contact: Eldad Tzahor
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