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217 technologies found
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BioRap Technologies and the Lipid Research Laboratory of the Rappaport Family Institute are offering collaboration for the identification of antioxidant and anti - atherogenic properties of nutritional antioxidants The lipid research laboratory, headed by Professor Michael Aviram, focuses its ...
BackgroundOrganic compounds from terrestrial and marine organisms have extensive past and present use in the treatment of many diseases and serve as compounds of interest both in their natural form and as templates for synthetic modification. Over 20 new drugs launched on the market between 2000 ...
Scientific Contact: Fuad Fares
Keywords Drug Delivery, Formulation Current development stage TRL7, Prototype and proprietary list of approved drugs that benefit from liposomal formulations Application Most active pharmaceutical ingredients (APIs) are not suitable for “passive” loading into ...
Scientific Contact: Amiram Goldblum
Cerebrovascular dysfunction is a fundamental part of the pathology of several neurodegenerative diseases and rated as one of the most prominent cause for dementia. Cerebral amyloid angiopathy (CAA) results in intra-parenchymal and subarachnoid bleeding, which is caused by cerebrovascular ...
Scientific Contact: Dan Frenkel
Technology SVEP1 is a novel cell adhesion protein. Its expression is primarily associated with bone cells but is also expressed by breast carcinoma cells. Anti-SVEP1 antibodies block cell adhesion in in vitro matrix. Prevention of cell adhesion by anti-SVEP1 antibodies will: · ...
Scientific Contact: Dafna Benayahu
TechnologyThe aggregation site on human calcitonin has been identified, paving the way for development of specific inhibitors of calcitonin amyloid fibril formation. Such inhibitors will enable development of improved calcitonin therapeutics as well as greatly facilitate in vitro calcitonin ...
Scientific Contact: Ehud Gazit
Selective therapy remains a key issue for successful treatment in cancer therapy. Prolonged administration of effective concentrations of chemotherapeutic or anti-angiogenic agents is usually not possible because of dose-limiting systemic toxicities involving non-malignant tissues. Therefore, a ...
Scientific Contact: Ronit Satchi-Fainaro
Lab DescriptionThe goal of the lab is to elucidate molecular mechanisms of motor neuron survival and proper function using ALS disease as a model.In our current efforts we are using cutting edge in vitro and in vivo technologies studying molecular mechanisms of: 1. Molecular communication ...
Scientific Contact: Eran Perlson
Research focus ErbB receptors interactions and functions Regulation of Autophagy Neurodegeneration Projects include:The crosstalk between ErbB receprots and nucleolin in cancer developmentBeclin 1 mediated autophagyAutophagy in neurodegenerative diseasesAutophagy in cancer Potential ...
Scientific Contact: Ronit Pinkas-Kramarski
Lab DescriptionMain areas of interest are in the mechanisms of protein folding and trafficking in the early secretory pathway of mammalian cells and the development of ER stress upon their malfunction, particularly in neurodegenerative diseases. Specific research topics are:• Protein ...
Research focusProf. Ben-Baruch is an immunologist who investigates the roles of immune and inflammatory elements in physiological and pathological conditions, with major emphasis on malignancy. The studies in her laboratory determine the complex regulatory networks established between ...
Scientific Contact: Adit Ben-Baruch
Lab Description Using the powerful combination of molecular biology, biophysics, biochemistry and electrophysiology. our research aims at elucidating the structural, biophysical and physiological attributes of normal and diseased ion channels in brain and heart and whose mutations in human ...
Scientific Contact: Bernard Attali
Cell-penetrating peptides (CPPs) have been successfully used for intracellular delivery of a broad variety of cargoes including various nanoparticulate pharmaceutical carriers (liposomes, micelles, nanoparticles, polymer-conjugates). However the cationic nature of all CPP sequences and thus lack of ...
Scientific Contact: Ayelet David
Liposomal Hemin for Anticancer Treatment Prof. Jonathan Leor, Head of the Cardiovascular Research Institute at Tel-Aviv University and Sheba Medical Center and Prof. Margalit Rimona, The Department of Biochemistry and Molecular Biology, Tel Aviv University THE NEED Myocardial infarction (MI) ...
Prof. Lior Gepstein's hiPSCs (human induced pluripotent stem cells) approach for modeling inherited cardiac disorders, such as Pompe glycogen storage disease, congenital long QT syndrome type II, CPVT and ARVC, has many implications in cardiovascular regenerative medicine, drug discovery, disease ...
An innovative platform for drug screening, toxicology testing and exploration of nevel means for treating severe cardiac pathologies, has been generated by Prof. Binah, focusing on inherited cardiac diseases such as Long Q-T Syndrome (LQTS), Catecholaminergic Polymorphic Ventricular Tachycardia ...
The Device rLLLT is a remote (non-invasive) Low Level Laser Therapy to the tibia of AMI patients. rLLLT mobilizes autologous bone marrow stem cells into the blood stream, where they home to the ischemic organ, induce paracrine secretion of growth factors, enhancing cytoprotection, ...
Scientific Contact: Uri Oron
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