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223 technologies found
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Background:The actin cytoskeleton and its regulatory proteins are significant players in cell movement, tissue invasion and metastasis by cancerous cells. For these to occur, actin polymerization and remodeling is required. The Wiskott-Aldrich syndrome protein (WASp) is an actin nucleation ...
Scientific Contact: Mira Barda-Saad
Novel bio-adhesives based on the natural polymers, gelatin (protein) and alginate (polysaccharide), and a carbodiimide crosslinking agent. The carbodiimide crosslinking agent is much less toxic than other crosslinking agents used in bioadhesives and therefore our bioadhesives exhibit enhanced ...
Scientific Contact: Meital Zilberman
The present invention relates to heparanase-neutralizing monoclonal antibodies (m Abs), pharmaceutical composition comprising same, and use thereof for treating a disease or disorder associated ...
TechnologyStabilized human IAPP (hIAPP) oligomers were used for the development of active immunization of type 2 diabetes. This promising novel approach for the treatment of type 2 diabetes is doable due to the establishment of a new protocol for the formation of stable islet amyloid ...
Scientific Contact: Ehud Gazit
BioRap Technologies and the Lipid Research Laboratory of the Rappaport Family Institute are offering collaboration for the identification of antioxidant and anti - atherogenic properties of nutritional antioxidants The lipid research laboratory, headed by Professor Michael Aviram, focuses its ...
BackgroundOrganic compounds from terrestrial and marine organisms have extensive past and present use in the treatment of many diseases and serve as compounds of interest both in their natural form and as templates for synthetic modification. Over 20 new drugs launched on the market between 2000 ...
Scientific Contact: Fuad Fares
Cerebrovascular dysfunction is a fundamental part of the pathology of several neurodegenerative diseases and rated as one of the most prominent cause for dementia. Cerebral amyloid angiopathy (CAA) results in intra-parenchymal and subarachnoid bleeding, which is caused by cerebrovascular ...
Scientific Contact: Dan Frenkel
Technology SVEP1 is a novel cell adhesion protein. Its expression is primarily associated with bone cells but is also expressed by breast carcinoma cells. Anti-SVEP1 antibodies block cell adhesion in in vitro matrix. Prevention of cell adhesion by anti-SVEP1 antibodies will: · ...
Scientific Contact: Dafna Benayahu
TechnologyThe aggregation site on human calcitonin has been identified, paving the way for development of specific inhibitors of calcitonin amyloid fibril formation. Such inhibitors will enable development of improved calcitonin therapeutics as well as greatly facilitate in vitro calcitonin ...
Scientific Contact: Ehud Gazit
Commercial Advantages Our invention is a platform for a new group of sun–related products with a versatile range of compounds with high applicability for cosmetic and pharmaceutical formulations. The new class of sunscreens is prepared from natural and synthetic available materials ...
Scientific Contact: Elka Touitou
Selective therapy remains a key issue for successful treatment in cancer therapy. Prolonged administration of effective concentrations of chemotherapeutic or anti-angiogenic agents is usually not possible because of dose-limiting systemic toxicities involving non-malignant tissues. Therefore, a ...
Scientific Contact: Ronit Satchi-Fainaro
Lab DescriptionThe goal of the lab is to elucidate molecular mechanisms of motor neuron survival and proper function using ALS disease as a model.In our current efforts we are using cutting edge in vitro and in vivo technologies studying molecular mechanisms of: 1. Molecular communication ...
Scientific Contact: Eran Perlson
Research focus ErbB receptors interactions and functions Regulation of Autophagy Neurodegeneration Projects include:The crosstalk between ErbB receprots and nucleolin in cancer developmentBeclin 1 mediated autophagyAutophagy in neurodegenerative diseasesAutophagy in cancer Potential ...
Scientific Contact: Ronit Pinkas-Kramarski
Lab DescriptionMain areas of interest are in the mechanisms of protein folding and trafficking in the early secretory pathway of mammalian cells and the development of ER stress upon their malfunction, particularly in neurodegenerative diseases. Specific research topics are:• Protein ...
Research focusProf. Ben-Baruch is an immunologist who investigates the roles of immune and inflammatory elements in physiological and pathological conditions, with major emphasis on malignancy. The studies in her laboratory determine the complex regulatory networks established between ...
Scientific Contact: Adit Ben-Baruch
Lab Description Using the powerful combination of molecular biology, biophysics, biochemistry and electrophysiology. our research aims at elucidating the structural, biophysical and physiological attributes of normal and diseased ion channels in brain and heart and whose mutations in human ...
Scientific Contact: Bernard Attali
Cell-penetrating peptides (CPPs) have been successfully used for intracellular delivery of a broad variety of cargoes including various nanoparticulate pharmaceutical carriers (liposomes, micelles, nanoparticles, polymer-conjugates). However the cationic nature of all CPP sequences and thus lack of ...
Scientific Contact: Ayelet David
Liposomal Hemin for Anticancer Treatment Prof. Jonathan Leor, Head of the Cardiovascular Research Institute at Tel-Aviv University and Sheba Medical Center and Prof. Margalit Rimona, The Department of Biochemistry and Molecular Biology, Tel Aviv University THE NEED Myocardial infarction (MI) ...
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ITTN - Israel Tech Transfer Organization