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223 technologies found
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Delivers treatment in response to pH conditions in mouth Categories Coatings, Biomaterials, Polymers, Composites, Dental Care Development Stage Successful clinical trials – ready for commercialization Patent Status Patent pending Highlights Novel dental coating ...
Scientific Contact: Michael Friedman
Corroles are synthetic, porphyrin molecules that can act as catalytic antioxidants. Corrole derivatives can be used for lowering the probability of developing chronic kidney disease, especially diabetic nephropathy, for which there are currently no approved therapeutic drugs. Additionally, they ...
Focused ion beam (FIB) technology is widely used in the semiconductor industry. FIB etching is used to develop and modify optoelectronic and microelectronic devices. However, FIB technology is limited to large scale devices and is incompatible with the industry trend to reduce device dimensions. ...
Cell death can occur through two main mechanisms, apoptosis or necrosis. Apoptosis is a tightly regulated physiological process and many of the biochemical pathways involved are well characterized. Necrosis, the outcome of severe and acute injury, has been until lately generally viewed as an ...
Scientific Contact: Eli Lewis
We have developed the signal attenuation rat model of obsessive-compulsive disorder (OCD). This model is based on the theoretical proposition that compulsive behaviors result from a deficit in the feedback, which is associated with the performance of normal goal-directed responses. In our ...
Scientific Contact: Daphna Joel
OUTLINE CD38 is an ectoenzyme that generates Ca2+ mobilizing agents and regulates nicotinamide adenine dinucleotide (NAD) levels. We showed that via its enzymatic activity CD38 promotes the supporting role of tumor microenvironment (TME) cells in brain and extracranial cancers.1-3 In addition, ...
Scientific Contact: Reuven Stein
EG-30: clinical phase drug for AMD and Glaucoma EG-30 – the highlights: · Excellent safety profile in healthy volunteers and glaucoma patients • Low systemic exposure • No increase in IOP in glaucoma patients treated with EG-30 for 16days (eye ...
Scientific Contact: Ehud Gazit
Lysosomal Storage diseases (LSD) are inherited genetic defects, resulting in an enzyme deficiency. This deficiency prevents the lysosome from metabolizing cellular waste, and results in their accumulation in the cell. Excessive storage of proteins, saccharides and/or fats can cause permanent ...
Scientific Contact: Ruth, Emeritus Navon
Novel fusion proteins enable ERT for the first time Categories Peptide/Protein, Metabolic, Protein Therapy Development Stage Proof of concept for LAD deficiency and Friedrich Ataxia, in vivo studies in mice Patent Status National Phase Market DNA mutations in ...
Scientific Contact: Haya Galski- Lorberboum
Isolated peptides from the protein EMMPRIN (CD147/Basigin) and antibodies directed against antigenic determinants within the ...
The invention, provides a method and a device for delivery of foam to a target site of a respiratory ...
Background:According to the amyloid hypothesis, accumulation and oligomerization of amyloid β-peptide (Aβ) in the brain because of its inefficient clearance is the primary pathogenic event in Alzheimer’s disease (AD). In healthy brains, soluble Aβ is rapidly cleared via mechanisms that ...
Scientific Contact: Shai Rahimipour
Gamma-ray detector (Technion)
Gamma-ray detectors have wide applications in fields such as nuclear medicine, environmental monitoring and material testing. By analyzing emitted rays using a gamma-ray spectrometer, diagnostically useful information can be obtained. Some of the methods used for the detection of gamma-rays ...
Keywords IBD, probiotic bacteria Current development stage TRL3 Experimental proof of concept; Initial demonstration of activity in vivo Our Innovation Genetically engineered probiotic bacteria for the local treatment of inflammatory Bowel Condiftions Opportunity The ...
Scientific Contact: Gabriel Nussbaum
Noam Shomron, PhDHead, MicroRNA Research LaboratoryHead, Tel Aviv University Genome High-Throughput Sequencing Laboratory Department of Cell & Developmental BiologySackler Faculty of Medicine, Room 301Tel Aviv University, Israel, 69978Tel-office: +972-3-640-6594Tel-lab: +972-3-640-7387Fax: ...
Scientific Contact: Noam Shomron
Technology Novel Glycogen synthase kinase 3 (GSK-3) inhibitors were developed. These inhibitors are substrate competitors that interact specifically with the GSK-3 substrate binding site. The strategy is based on exploiting the unique GSK-3-substrate’s binding motifs as extracted from ...
Scientific Contact: Hagit Eldar- Finkelman
The Technology Guided regeneration gel (GRG) is a novel biocompatible, biodegradable hydrogel for peripheral nerve reconstruction, cell therapy and wound healing. Similar to the extracellular matrix (ECM), GRG is transparent, highly viscous, malleable, and adaptable to various shapes and ...
Scientific Contact: Zvi, Emeritus Nevo
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ITTN - Israel Tech Transfer Organization